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CAS No.: 481-49-2

千金藤素 Catalog No. CSN19471

Synonyms: NSC-623442;O-Methylcepharanoline;6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis- (oxy)]oxyacanthan

Cepharanthine is a naturally occurring alkaloid extracted from the plant Stephania cepharantha Hayata. It possesses potency of antiinflammatory, antineoplastic and effect against HTLV.

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技术信息

生物活性

描述Cepharanthine is an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities. CEP (Cepharanthine) dose-dependently inhibited the release of TNF-α, IL-6, and IL-1β in LPS-stimulated RAW264.7 cells. Significantly, CEP dose-dependently suppressed NF-κB activation, IκBα degradation, and phosphorylation of ERK, JNK, and p38 induced by LPS. In vivo, it was also observed that CEP attenuated lung histopathologic changes and down-regulated the level of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, in the mouse acute lung injury model^[3]. CEP inhibited Ca2+-induced swelling, depolarization, Cyt.c release, and the release of Ca2+ in a concentration dependent manner. CEP also inhibited Ca2+-induced generation of reactive oxygen species and Fe/ADP-induced swelling and lipid peroxidation. Furthermore, CEP suppressed Ca2+-induced thiol modification of adenine nucleotide transloase (ANT)^[4]. Cepharanthine attenuates muscle and kidney injuries induced by limb ischemia/reperfusion (I/R)^[5]. CEP attenuates cerebral I/R injury probably by inhibiting microglia activation and NLRP3 (NLR Family Pyrin Domain Containing 3) inflammasome-induced inflammation and reducing oxidative stress via suppressing 12/15-LOX signaling^[6]. CEP could inhibit growth and motility of MCF-7 and MDA-MB-231 breast cancer cell^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6482 mL
- 8.2412 mL
- 16.4824 mL
- 5 mM
- 0.3296 mL
- 1.6482 mL
- 3.2965 mL
- 10 mM
- 0.1648 mL
- 0.8241 mL
- 1.6482 mL

技术信息

CAS号

481-49-2

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C37H38N2O6

运输

蓝冰

分子量

606.71

别名

NSC-623442;O-Methylcepharanoline;6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis- (oxy)]oxyacanthan;Cepharanthin;千金藤碱;千金藤素

溶解度

DMSO	98.0 mg/mL (161.5 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

2%DMSO+30% PEG 300+5% Tween 80+water

5 mg/mL

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